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Interstate 75 (I-75) is a part of the Interstate Highway System that runs from Miami, Florida, to Sault Ste. Marie in the Upper Peninsula of Michigan. It crosses into western Ogemaw County where it has two exits into the I-75 business loop running through the city of West Branch, Michigan.

West Branch is accessible at exit 212 and 215. Rose City and Prescott are accessible at exit 202.

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Ogemaw County Highways

Interstate 75 (I-75)

Known as "Michigan's Main Street", I-75 is listed on the National Highway System (NHS) for its entire length. I-75 carries segments of all four Great Lakes Circle Tours in the state. It is also the only highway located on both Michigan's Upper and Lower peninsulas (UP and LP, respectively).

Interstate 75 Business Loop (BL I-75)

Interstate 75 Business Loop, or BL I-75 is a loop route running through West Branch, Michigan. It was first commissioned as BUS M-76 before the complete decommissioning of M-76 in Michigan in favor of I-75.

Michigan Highway 30 (M-30)

M-30 runs in a north–south direction from the Midland area to West Branch. The southern end runs along the Michigan Meridian and parallel to the Tittabawassee River. In May 2009, M-30 was extended southerly from US 10 to M-20, restoring some of the highway decommissioned in the 1960s to M-30.

Michigan Highway 33 (M-33)

M-33 is a Michigan highway that runs from Interstate 75 (I-75) at Alger in Arenac County north to M-27 near Cheboygan. In between, the trunkline runs through rural sections of the northeastern Lower Peninsula including state and national forest areas. M-33 connects to a handful of parks and crosses several of the rivers in that section of the state.

Michigan Highway 55 (M-55)

M-55 is one of only three state highways that extend across the Lower Peninsula from Lake Huron to Lake Michigan. The highway crosses through rural forest and farmlands to connect Manistee with Tawas City. M-55 crosses two of the major rivers in the state. Two sections of the highway follow along freeways near Cadillac and West Branch. Running for 150 miles through the state.

Michigan F-18

F-18 follows Greenwood Road easterly from F-97 south of St. Helen through Skidway Lake and Prescott to the Iosco/Ogemaw county line. It then follows McLean Road southerly along this line to end at the juncture of the Iosco, Ogemaw and Arenac county lines. Official MDOT maps show the route ending at the Ogemaw/Roscommon county line, although the F-18 designation is signed along Greenwood Road in Ogemaw County.

Michigan F-28

F-28 runs from F-97 in St. Helen, along Rose City Road through Rose City and Lupton to the Iosco/Ogemaw County line. The route starts easterly along Mercury Road (the Iosco County portion of Rose City Road), jogged northerly on South Branch Road, then easterly via Kokosing Road to end at M-65 north of Hale.